Central nervous insulin administration does not potentiate the acute glucoregulatory impact of concurrent mild hyperinsulinemia Short title: Brain insulin and glucose homeostasis in humans
نویسندگان
چکیده
1 Department of Neuroendocrinology, University of Lübeck, 23538 Lübeck, Germany; 2 Department of Internal Medicine I, University of Lübeck, 23538 Lübeck, Germany; 3 Department of Medical Psychology and Behavioral Neurobiology, University of Tübingen, 72076 Tübingen, Germany; 4 German Center for Diabetes Research (DZD), 72076 Tübingen, Germany; 5 Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen (IDM), 72076 Tübingen, Germany.
منابع مشابه
Central nervous insulin administration does not potentiate the acute glucoregulatory impact of concurrent mild hyperinsulinemia.
Experiments in rodents suggest that hypothalamic insulin signaling essentially contributes to the acute control of peripheral glucose homeostasis. Against this background, we investigated in healthy humans whether intranasal (IN) insulin, which is known to effectively reach the brain compartment, impacts systemic glucose metabolism. Twenty overnight-fasted healthy, normal-weight men were IN adm...
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